Parent Perceptions Drive Diets of Children With AD

Approximately one third of parents of children with atopic dermatitis (AD) reported little or no improvement with elimination diets, and nearly 80% reintroduced the eliminated foods, based on survey data from nearly 300 parents.
Although AD can be associated with an increased risk for food allergies, major allergy organizations do not currently recommend elimination diets as a treatment for AD, said Nadia Makkoukdji, MD, a pediatrician at Jackson Memorial Hospital, Miami, in a presentation at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting.
“A fear of drastic dietary changes often prevents families from seeking the care their children need,” Makkoukdji said in an interview. In the clinical setting, Makkoukdji noted that she has seen many patients who have started food elimination diets on their own or as recommended by other doctors, and that these diets can lead to dangers such as the development of immunoglobulin E–mediated food allergies on reintroduction of eliminated foods and malnutrition. They can also produce “emotional stress in children and anxiety or depression, while also adding stress to parents and the entire family.”
Makkoukdji conducted the study to explore parents’ perceptions of these diets in management of their children’s AD, she said.
In the study, Makkoukdji and colleagues sought to understand parents’ perceptions of the role of diet in AD in their children. The researchers reviewed surveys from 298 parents of children with AD who were seen at a single academic center. Parents completed the surveys in the emergency department or in an allergy, dermatology, and general pediatrics clinic.
Overall, 42% of parents identified food triggers for their child’s AD. The most commonly identified triggers were milk (32%), tree nuts/seeds/peanuts (16%), and eggs (11%).
Of the parents who reported food triggers, 23% removed the suspected trigger food from the child’s diet completely, 20% removed suspected trigger foods from their own diets while breastfeeding, and 19% changed their infant’s formula.
In the wake of the elimination diets, 38% of the parents reported no improvement in their child’s AD, 35% reported a 25% improvement, and 9% reported complete resolution. The majority (79%) reintroduced eliminated foods and reported no recurrence of AD symptoms.
The researchers were surprised by how many parents changed their child’s diet in the belief that certain foods exacerbated their child’s AD, “although this perception aligns with the common concern that food allergens can trigger or worsen atopic dermatitis flares,” Makkoukdji told Medscape Medical News.
The current study highlights the need for more awareness of the limited impact of dietary modifications on AD in the absence of confirmed food allergies, Makkoukdji said. “Our study shows that food elimination diets are still commonly being used by parents in the local Miami population,” she noted.
The findings were limited by several factors, including the use of data from a single center and the focus only on pediatric patients, but the primary goal was to assess parental perceptions of AD flares in relation to dietary choices, said Makkoukdji. “Future studies that include larger and more diverse populations would be valuable for the field,” she said.
Dietary Modifications Don’t Live Up to Hype
“Food continues to be one of the most discussed aspects of atopic dermatitis,” said Peter Lio, MD, clinical assistant professor of dermatology and pediatrics at Northwestern University Feinberg School of Medicine, Chicago, in an interview.
“Almost all of my patients and families ask about dietary modifications, even though almost all of them have experimented with it to some degree,” said Lio. In his experience, diet plays a small role, if any, in the day-to-day management of AD.
This lack of effect of dietary changes is often frustrating to patients because of the persistent “common wisdom” that points to diet as a root cause of AD, Lio told Medscape Medical News. “Many practitioners continue to recommend excluding foods such as gluten or dairy from the diet, but generally these are only of modest help,” and although patients wish that dietary changes would fix the problem, most are left wondering why these changes didn’t help them, he said.
The current study findings “reflect my own experience after nearly 20 years of being deeply immersed in the world of atopic dermatitis,” Lio told Medscape Medical News. Although the takeaway message does not argue against eating healthy foods, some foods do seem to make AD worse in some patients and may have nonallergic pro-inflammatory effects, he said.
“In those cases, it is reasonable to limit or avoid those foods. However, it is extremely difficult to tell what food or foods are driving flare-ups when things are out of control, so dietary modification is generally not the best place to start,” he said.
True food allergies are much more common in patients with AD compared with individuals without AD, but the current study is not addressing these types of allergies, Lio emphasized. “If someone has true allergy to peanuts, for example, they should not be eating them; we also know that they are not ‘cheating’ because these patients would not merely have an eczema flare; they would have urticaria, angioedema, or anaphylaxis,” he said. “There is tremendous confusion around this point and lots of confusion around allergy testing and its limitations,” Lio added.
In addition, patients with AD are more likely than those without AD to have abnormalities in the gut microbiome and gut barrier, Lio told Medscape Medical News.
Abnormalities in the gut microbiome are different from the concept of allergy and may fall into the more complex category of barrier and microbiome disruptors, he said. Therefore, “the food category may not be nearly as important as the specific preparation of the food along with the additives (such as preservatives and emulsifiers) that may actually be driving the problem,” he noted.
Although in the past many clinicians advised patients to try cutting out certain foods to see whether AD symptoms improved, this strategy is not without risk, said Lio. “There have been incredible advancements in understanding the role of the gut in tolerization to foods,” he said. Recent research has shown that by eating foods regularly, particularly those such as peanuts that seem to have more allergic potential, the body becomes tolerant, and this prevents the development of true food allergies, he said.
As for additional research, many questions remain about the effects of types of foods, processing methods, and timing of introduction of foods on AD, Lio noted.
“Atopic dermatitis is a systemic condition with the immune system, with the skin/gut/respiratory barriers and microbiome involved; I think we now have a broader view of how big and complex the landscape really is,” he said.
The study received no outside funding. The researchers had no financial conflicts to disclose. Lio had no disclosures relevant to elimination diets but disclosed serving on the speakers bureau for AbbVie, Arcutis Biotherapeutics, Eli Lilly and Company, Galderma, Hyphens Pharma, Incyte, La Roche-Posay/L’Oréal, Pfizer, Pierre Fabre Dermatologie, Regeneron/Sanofi Genzyme, and Verrica Pharmaceuticals; serving on consulting/advisory boards; or having stock options for many pharmaceutical companies. Lio also disclosed a patent pending for a Theraplex product with royalties paid and is a board member and Scientific Advisory Committee member emeritus of the National Eczema Association.
Heidi Splete is a medical writer based in Bethesda, Maryland.
 
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